NLRP3 Inflammasome Expression and Urinary HSP72 In Relation to Biomarkers of Inflammation and Oxidative Stress in Diabetic Nephropathy Patients

Document Type : Abstracts

Abstract

Diabetic nephropathy (DN) is  one  of  the  major causes  of  end-stage  renal  disease.  Nod-like receptors nucleotide-binding domain and leucine-rich repeat pyrin-3 domain (NLRP3  (inflammasome displays a considerable role in the chronic inflammatory state observed in  diabetic patients. Urinary heat shock protein 72 (uHSP72) is a sensitive and specific biomarker  for the early detection the acute kidney injury.