The Emerging Role of the Epigenetic Enzyme Sirtuin-1 And High Mobility Group Box 1 in Patients with Diabetic Foot Ulceration

Document Type : Abstracts

Abstract

Diabetic foot ulceration (DFU) is a serious diabetic complication that can progress to amputation and since SIRT1 regulates glucose metabolism, inflammation, and oxidative stress which are the major contributors in diabetic complications, so we aimed to discuss its role as an epigenetic biomarker in DFU and highlight its link to oxidative stress and inflammatory cytokines.