The Role of Circulating Soluble Fms-Like Tyrosine Kinase-1 In Patients with Diabetic Foot Ulcer: A Possible Mechanism of Pathogenesis Via a Novel Link Between Oxidative Stress, Inflammation and Angiogenesis

Document Type : Abstracts

Abstract

Diabetic foot ulcer (DFU) is one of the most devastating diabetic consequences leading to amputations. Oxidative stress, inflammation, vascular insufficiency and neuropathy have been linked to DFU development. Since soluble fms-like tyrosine kinase-1 (sFlt-1) is one of the anti-angiogenic factors regulating vascular endothelial growth factor (VEGF) biological activity. So, we aimed to evaluate its role in the pathogenesis of DFU and its correlation with oxidative stress and inflammatory markers. 

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